Mapping DNA’s Folds: UIC-led Team Uses Powerful Computers to Unfurl Genomic Secrets

A single-cell 3D simulation of chromatin, the structures that make up the chromosome.

For decades, scientists have probed how human DNA that would stretch more than 2 meters if unspooled from a cell is packed into chromosomes millions of times smaller.

A single-cell 3D simulation of chromatin, the structures that make up the chromosome. The beads represent monomers, a segment of the genome, linked to form a polymer. The colors delineate distance along the genome. Image credit: Jie Liang, University of Illinois Chicago.

What’s more, they’ve tried to learn how this extreme folding influences genes. They way genes are packed into chromosomes can produce cells that smoothly develop into organs and bones or that misfire and lead to disease.

The post Mapping DNA’s Folds: UIC-led Team Uses Powerful Computers to Unfurl Genomic Secrets appeared first on HPCwire.

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