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This illustration shows how the TFIIH protein complex changes its structure to execute different functions The TFIIH subunits are colored as follows XPD red p62 blue p44 orange p34 green p52 purple p8 light grey XPB pink MAT1 and XPA are shown in yellow and DNA is cyan PACE Engineering Recruiters

Transcription factor IIH, or TFIIH, pronounced “TF two H,” is a veritable workhorse among the protein complexes that control human cell activity. It plays critical roles both in transcription — the highly regulated enzymatic synthesis of RNA from a DNA template — and in the repair of damaged DNA. But how can one protein assembly participate in two such vastly different and extremely important genomic tasks?

The post Georgia State Researchers Use Summit Supercomputer to Gain New Insights into DNA Repair appeared first on HPCwire.

Article From: "Andrew Jolly"   Read full article »


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