UChicago Scientists Uncover How HIV Invades Cell Nucleus with Help from TACC’s Frontera

A new study from two University of Chicago (UChicago) scientists has revealed how HIV squirms its way into the nucleus as it invades a cell.

According to their models, the HIV capsid, which is cone-shaped, points its smaller end into the pores of the nucleus and then ratchets itself in. Once the pore is open enough, the capsid is elastic enough to squeeze through. Importantly, the scientists said, both the structural flexibility of the capsid and the pore itself play a role in the infiltration process.

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